Adult Gonadal Hormones Selectively Regulate Sexually Dimorphic Quantitative Traits Observed in Experimental Allergic Encephalomyelitis
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چکیده
منابع مشابه
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.
We previously used high-density expression arrays to interrogate a genetic cross between strains C3H/HeJ and C57BL/6J and observed thousands of differences in gene expression between sexes. We now report analyses of the molecular basis of these sex differences and of the effects of sex on gene expression networks. We analyzed liver gene expression of hormone-treated gonadectomized mice as well ...
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BACKGROUND The densely staining sexually dimorphic nucleus of the preoptic area (SDNPOA) is profoundly affected by gonadal steroids during perinatal development. METHODS We tested whether the SDNPOA in rats also remains responsive to gonadal hormones in adulthood. RESULTS Castration of 60-day-old male rats led to a reduction of soma size in SDNPOA neurons 28 days later, but not 14 days late...
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The classic view of brain sexual differentiation and behavior is that gonadal steroid hormones act directly to promote sex differences in neural and behavioral development. In particular, the actions of testosterone and its metabolites induce a masculine pattern of brain development, while inhibiting feminine neural and behavioral patterns of differentiation. However, recent evidence indicates ...
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To understand the mechanisms of morphological evolution and species divergence, it is essential to elucidate the genetic basis of variation in natural populations. Sexually dimorphic characters, which evolve rapidly both within and among species, present attractive models for addressing these questions. In this report, we map quantitative trait loci (QTL) responsible for variation in sexually d...
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Sexual conflict at loci influencing traits shared between the sexes occurs when sex-specific selection pressures are antagonistic relative to the genetic correlation between the sexes. To assess whether there is sexual conflict over shared traits, we estimated heritability and intersexual genetic correlations for highly sexually dimorphic traits (horn volume and body mass) in a wild population ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2004
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63107-0